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CD45 Antibody

CAT: 0800-V8396SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8396SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out) . The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Western blot: 1-2 µg/mL
UniProt
P08575
Host
Mouse
Reactivity
Human
Immunogen
Human recombinant full-length protein was used as the immunogen for the CD45 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
PTPRC/1666
Applications
FACS, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the CD45 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD45 antibody is available for research use only.
Storage Conditions
Store the CD45 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the CD45 antibody should be determined by the researcher.
Location
Cell surface
Image Legend
Flow cytometry testing of PFA-fixed human Jurkat cells with CD45 antibody (clone PTPRC/1666) ; Red=isotype control, Blue= CD45 antibody.

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