C3d / Complement 3d Antibody

C3d / Complement 3d Antibody

• Description: The complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH- and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity.
• CAS Number: 9007-83-4
• UniProt: P01024
• Host: Mouse
• Immunogen: A portion of amino acids 1250-1450 from human Complement C3 protein was used as the immunogen for this Complement 3d antibody.
• Clonality: Monoclonal
• Isotype: IgG2b κ
• Applications: IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Reconstitution: Store the Complement 3d antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This Complement 3d antibody is available for research use only.