Thyroid Peroxidase Recombinant Antibody

• Description:

  Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

• UniProt:

  P07202

• Host:

  Rabbit

• Immunogen:

  A recombinant human partial protein (amino acids 685-804) was used as the immunogen for this TPO antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG κ

• Type:

  Recombinant

• Applications:

  IHC-P

• Format:

  Purified

• Buffer:

  1 mg/ml in 1X PBS; BSA free, sodium azide free

• Reconstitution:

  Store the recombinant Thyroid Peroxidase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This recombinant Thyroid Peroxidase antibody is available for research use only.

• CAS Number:

  9000-83-3