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SREBP1 Antibody

CAT: 0800-V8099-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8099-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1) . When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P36956
Host
Mouse
Reactivity
Human
Immunogen
A recombinant full-length human protein was used as the immunogen for this SREBP1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
SREBP1/1578
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the SREBP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This SREBP1 antibody is available for research use only.
Storage Conditions
Store the SREBP1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the SREBP1 antibody should be determined by the researcher.
Image Legend
SDS-PAGE analysis of purified, BSA-free SREBP1 antibody (clone SREBP1/1578) as confirmation of integrity and purity.

UniProtKB · P36956

Sterol regulatory element-binding protein 1

SRBP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P36956
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SREBF1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SREBP-1
EC number
—
Processing
—
Secondary accessions
B0I4X3, B0I4X4, D3DXC4, Q16062, Q59F52, Q6P4R7, Q6PFW7, Q6PJ36, Q8TAK9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Cholesterol metabolismLipid metabolismSteroid metabolismSterol metabolismTranscriptionTranscription regulation

Cellular component

Cytoplasmic vesicleEndoplasmic reticulumGolgi apparatusMembraneNucleus

Disease

Disease variantIchthyosis

PTM

PhosphoproteinUbl conjugation

Domain

TransmembraneTransmembrane helix

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