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RET Antibody

CAT: 0800-V8055-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V8055-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system; in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney. Alterations in RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung's disease.
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating)
UniProt
P07949
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 702-848) was used as the immunogen for this RET antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
RET/2599
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the RET antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This RET antibody is available for research use only.
Storage Conditions
Store the RET antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the RET antibody should be determined by the researcher.
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using RET antibody (clone RET/2599) . These results demonstrate the foremost specificity of the RET/2599 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

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