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PAX5 Antibody

CAT: 0800-V7997-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7997-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding domain, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis; therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q02548
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 235-382) was used as the immunogen for the PAX5 antibody.
Clonality
Monoclonal
Isotype
IgG1 λ
Clone
PAX5/3735
Applications
IHC-P, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the PAX5 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PAX5 antibody is available for research use only.
Storage Conditions
Store the PAX5 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the PAX5 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
IHC testing of human tonsil with PAX5 antibody. Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · Q02548

Paired box protein Pax-5

PAX5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q02548
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PAX5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A3QVP6, A3QVP7, A3QVP8, C0KTF6, C0KTF7, C0KTF8, C0KTF9, C0KTG0, O75933, Q5SFM2, Q6S728, Q6S729, Q6S730, Q6S731, Q6S732
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Molecular function

Developmental proteinDNA-binding

Biological process

DifferentiationNeurogenesisSpermatogenesisTranscriptionTranscription regulation

Disease

Disease variantProto-oncogene

PTM

Glycoprotein

Cellular component

Nucleus

Domain

Paired box

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