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CD25 Antibody

CAT: 0800-V7881-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7881-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 55kDa, identified as CD25. It is expressed on activated T- and B-cells and activated monocytes/macrophages. With respect to lymphomas, CD25 is present on malignant cells of Hodgkin's disease, HTLV-1+ adult T-cell leukemia, cutaneous T-cell lymphoma, and hair cell leukemia. Increased levels of soluble CD25 are observed in the leukemias/lymphomas and inflammatory/ autoimmune diseases. CD25 molecule alone appears to function as a low affinity receptor and associates with CD122 (IL-2R chain, p75) and CD132 (common chain) to form the high affinity IL-2 receptor complex. CD25 antibodies detect three epitope regions, A, B and C. This MAb recognizes the epitope B, which is located at residue 3-104 of CD25 and does not block IL-2 binding to CD25.
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating)
UniProt
P01589
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 42-183) was used as the immunogen for this CD25 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
IL2RA/2394
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CD25 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD25 antibody is available for research use only.
Storage Conditions
Store the CD25 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD25 antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using IL25 antibody (clone IL2RA/2394) . These results demonstrate the foremost specificity of the IL2RA/2394 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

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