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Gastrin Antibody

CAT: 0800-V7797SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7797SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gastrin, is a hormone that normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets. Its primary function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. It also responsible for stimulating smooth muscle contraction and increasing blood circulation and water secretion in the stomach and intestine. Gastrin is regulated by epidermal growth factor in both mice and humans. Gastrin is excreted in excess by pancreatic tumors in the Zollinger-Ellison syndrome. Gastrin-Releasing Peptide (GRP) stimulates the release of gastrin as well as other gastrointestinal hormones and also acts as an autocrine growth factor for certain cell types. High levels of GRP are found in the human lung just after birth and levels decrease thereafter in parallel with the observed disease in a number of pulmonary neuroendocrine cells. GRP is known to promote lung tumorigenesis in model systems.
CAS Number
9007-83-4
Specifications
Immunohistochemistry: 1-2 µg/mL
UniProt
P01350
Host
Mouse
Reactivity
Human
Immunogen
A recombinant full-length human GAST protein was used as the immunogen for this Gastrin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
GAST/2634
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the Gastrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Gastrin antibody is available for research use only.
Storage Conditions
Store the Gastrin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Gastrin antibody should be determined by the researcher.
Location
Cytoplasmic, secreted
Image Legend
IHC staining of FFPE human stomach with Gastrin antibody (clone GAST/2634) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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Alternative Products

CatalogName
20R-GR002Gastrin antibody
222878Gastrin (Gastrin, Gastrin-71, Gastrin 71, Gastrin71, Gastrin Component I, Gastrin-52, Gastrin 52, Gastrin52, Big gastrin, Gastrin Component II, Gastrin-34, Gastrin 34, Gastrin34, Gastrin, Gastrin Component III, Gastrin-17, Gastrin-14, Gastrin-6, Gastrin 17, Gastrin 14, Gastrin 6, Gastrin17, Gastrin14, Gastrin6, GAST, GAS)
030982Gastrin (GAST, GAS, Gastrin-71, Gastrin component I, Gastrin-52, Big gastrin, Gastrin component II, Gastrin-34, Gastrin component III, Gastrin-17, Gastrin-14, Gastrin-6)

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