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Cathepsin K Antibody

CAT: 0800-V7707-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7707-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P43235
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 163-274) was used as the immunogen for the Cathepsin K antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CTSK/2793
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Cathepsin K antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Cathepsin K antibody is available for research use only.
Storage Conditions
Store the Cathepsin K antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Cathepsin K antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
IHC staining of FFPE human hepatocellular carcinoma with Cathepsin K antibody (clone CTSK/2793) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.

UniProtKB · P43235

Cathepsin K

CATK_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P43235
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CTSK
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.22.38
Processing
Precursor
Secondary accessions
Q6FHS6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneLysosomeMembraneSecreted

Disease

Disease variant

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

HydrolaseProteaseThiol protease

Domain

Signal
Product Datasheet
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