CTLA-4 Antibody / CD152

• Description:

  This CTLA4 antibody is specific to the soluble form of the protein. CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule.

• UniProt:

  P16410

• Host:

  Mouse

• Immunogen:

  Amino acids CENAPNRARM were used as the immunogen for the CTLA4 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 κ

• Applications:

  WB

• Format:

  Purified

• Buffer:

  1 mg/ml in 1X PBS; BSA free, sodium azide free

• Reconstitution:

  Store the CTLA4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This CTLA4 antibody is available for research use only.

• CAS Number:

  9007-83-4