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PAPPA Antibody / Pappalysin-1

CAT: 0800-V7593SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7593SAF-100UGSize:100 µg
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Description
Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD) .
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q13219
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 351-523 from the human protein was used as the immunogen for the PAPPA antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
PAPPA/2717
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the PAPPA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PAPPA antibody is available for research use only.
Storage Conditions
Store the PAPPA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cytoplasmic
Image Legend
IHC staining of FFPE human placenta with PAPPA antibody (clone PAPPA/2717) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.

UniProtKB · Q13219

Pappalysin-1

PAPP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13219
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PAPPA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.24.79
Processing
Precursor
Secondary accessions
B1AMF9, Q08371, Q68G52, Q9UDK7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

HydrolaseMetalloproteaseProtease

Ligand

Metal-bindingZinc

Domain

RepeatSignalSushi

Cellular component

Secreted
Product Datasheet
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