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NKX3.1 Antibody

CAT: 0800-V7569-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7569-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.
CAS Number
9007-83-4
Specifications
ELISA (order BSA/sodium azide-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q99801
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human NKX3.1 protein fragment within amino acids 92-224 was used as the immunogen for the NKX3.1 antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
NKX3.1/2576
Applications
ELISA, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the NKX3.1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This NKX3.1 antibody is available for research use only.
Storage Conditions
Store the NKX3.1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Nuclear
Image Legend
IHC staining of FFPE human prostate carcinoma with NKX3.1 antibody (clone NKX3.1/2576) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.

UniProtKB · Q99801

Homeobox protein Nkx-3.1

NKX31_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99801
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NKX3-1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O15465, Q9H2P4, Q9H2P5, Q9H2P6, Q9H2P7, Q9HBG0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

DNA-bindingRepressor

Domain

Homeobox

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulation

Disease

Tumor suppressor

PTM

Ubl conjugation
Product Datasheet
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