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Recombinant TCL1 Antibody

CAT: 0800-V7369IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V7369IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
T-cell leukemia/Lymphoma Protein 1A (TCL-1A), also known as p14TCL1 is a product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (TPLL) . T-PLL is a rare form of mature T-cell leukemia, which is consistently associated with chromosomal rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and the TCL1A gene on 14q32.13. TCL1 is overexpressed in Burkitt lymphoma, the majority of AIDS-related non-Hodgkin lymphoma-designated immunoblastic plasmacytoid lymphoma, lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and primary cutaneous B-cell lymphoma.
CAS Number
9000-83-3
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P56279
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 2-109 from the human protein was used as the immunogen for the recombinant TCL1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
TCL1/2747R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the recombinant TCL1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant TCL1 antibody is available for research use only.
Storage Conditions
Store the recombinant TCL1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Nuclear, cytoplasmic
Image Legend
IHC testing of FFPE human tonsil with recombinant TCL1 antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P56279

T-cell leukemia/lymphoma protein 1A

TCL1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P56279
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TCL1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6IBK7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Chromosomal rearrangement

Cellular component

CytoplasmEndoplasmic reticulumMicrosomeNucleus

Disease

Proto-oncogene

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