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Recombinant MCM7 Antibody

CAT: 0800-V7360SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7360SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. [UniProt]
CAS Number
9000-83-3
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Prediluted IHC only format: incubate for 30 min at RT (1)
UniProt
P33993
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 195-319 from the human protein were used as the immunogen for the recombinant MCM7 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
MMCC7-1R
Type
Recombinant
Applications
IHC-P, WB
Purity
Protein A affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the recombinant MCM7 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant MCM7 antibody is available for research use only.
Storage Conditions
Store the recombinant MCM7 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Nuclear
Image Legend
IHC testing of FFPE human lymph node with recombinant MCM7 antibody (clone MMCC7-1R) . Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min.

UniProtKB · P33993

DNA replication licensing factor MCM7

MCM7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P33993
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MCM7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.6.4.12
Processing
—
Secondary accessions
A4D2A1, A4D2A2, E9PGN9, Q15076, Q96D34, Q96GL1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleDNA replication

Cellular component

ChromosomeNucleus

Molecular function

DNA-bindingHelicaseHydrolase

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