Topoisomerase II alpha Antibody / TOP2A

• Description:

  This mAb recognizes a 170kDa protein which is identified as Topoisomerase IIa, and shows no cross-reaction with Topoisomerase IIb or I. Topo IIa plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor cells.

• UniProt:

  P11388

• Host:

  Mouse

• Immunogen:

  Human recombinant partial protein (amino acids 1352-1493) was used as the immunogen for this TOP2A antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG2b κ

• Applications:

  WB, IF, IHC

• Format:

  Purified

• Buffer:

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

• Reconstitution:

  Store the TOP2A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This TOP2A antibody is available for research use only.

• CAS Number:

  9007-83-4