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CD63 Antibody / LAMP-3

CAT: 0800-V7190-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7190-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD63 functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. [UniProt]
CAS Number
9007-83-4
Specifications
Flow cytometry: 0.5-1ug/million cells in 0.1ml, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT (1), Prediluted IHC only format: incubate for 30 min at RT (2)
UniProt
P08962
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human full-length protein was used as the immunogen for the CD63 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
CDLA63-1
Applications
FACS, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CD63 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD63 antibody is available for research use only.
Storage Conditions
Store the CD63 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic
Image Legend
Flow cytometry testing of PFA-fixed human U-87 MG cells with CD63 antibody (clone CDLA63-1) ; Red=isotype control, Blue= CD63 antibody.

UniProtKB · P08962

CD63 antigen

CD63_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08962
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD63
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
F8VZE2, Q5TZP3, Q8N6Z9, Q9UCG6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneEndosomeLysosomeMembraneSecreted

PTM

GlycoproteinLipoproteinPalmitate

Biological process

Protein transportTransport

Domain

TransmembraneTransmembrane helix

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