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PGP9.5 Antibody

CAT: 0800-V7153-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7153-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UCHL1/PGP9.5 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of PGP9.5 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is abundantly present in all neurons (accounts for 1-2% of total brain protein), expressed specifically in neurons and testis/ovary. [Wiki]
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Prediluted IHC only format: incubate for 30 min at RT (1)
UniProt
P09936
Host
Mouse
Reactivity
Human, Rat
Immunogen
Recombinant human protein was used as the immunogen for the PGP9.5 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
UBCE-L1
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the PGP9.5 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PGP9.5 antibody is available for research use only.
Storage Conditions
Store the PGP9.5 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic, ER membrane
Image Legend
IHC testing of FFPE rat cerebellum with PGP9.5 antibody (clone UBCE-L1) . Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P09936

Ubiquitin carboxyl-terminal hydrolase isozyme L1

UCHL1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09936
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
UCHL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
UCH-L1
EC number
3.4.19.12
Processing
Precursor
Secondary accessions
Q4W5K6, Q71UM0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinLipoproteinOxidationPhosphoproteinPrenylation

Coding sequence diversity

Alternative initiation

Cellular component

CytoplasmEndoplasmic reticulumMembrane

Disease

Disease variantHereditary spastic paraplegiaNeurodegenerationParkinson diseaseParkinsonism

Molecular function

HydrolaseProteaseThiol protease

Biological process

Ubl conjugation pathway

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