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Involucrin Antibody

CAT: 0800-V7103SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7103SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Involucrin is a highly reactive, soluble, transglutaminase substrate protein present in keratinocytes of epidermis and other stratified squamous epithelia. It first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane functioning as a glutamyl donor during assembly of the cornified envelope. [Wiki]
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Prediluted IHC only format: incubate for 30 min at RT (1)
UniProt
P07476
Host
Mouse
Reactivity
Human
Immunogen
Purified protein was used as the immunogen for the Involucrin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
INVO49
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the Involucrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Involucrin antibody is available for research use only.
Storage Conditions
Store the Involucrin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human tonsil with Involucrin antibody (clone INVO49) . Staining of formalin-fixed tissues is enhanced by digestion with Trypsin or Protease XXV at 1 mg/mL PBS for 5 min at 37oC. Enzyme digestion is more effective than citrate buffer based epitope unmasking.

UniProtKB · P07476

Involucrin

INVO_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07476
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IVL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5T7P4
Protein keywords

Cellular component

Cytoplasm

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

Isopeptide bondLipoprotein

Biological process

Keratinization

Domain

Repeat

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