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Involucrin Antibody

CAT: 0800-V7103IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V7103IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Involucrin is a highly reactive, soluble, transglutaminase substrate protein present in keratinocytes of epidermis and other stratified squamous epithelia. It first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane functioning as a glutamyl donor during assembly of the cornified envelope. [Wiki]
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P07476
Host
Mouse
Reactivity
Human
Immunogen
Purified protein was used as the immunogen for the Involucrin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
INVO49
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the Involucrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Involucrin antibody is available for research use only.
Storage Conditions
Store the Involucrin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human tonsil with Involucrin antibody (clone INVO49) . Staining of formalin-fixed tissues is enhanced by digestion with Trypsin or Protease XXV at 1 mg/mL PBS for 5 min at 37oC. Enzyme digestion is more effective than citrate buffer based epitope unmasking.

UniProtKB · P07476

Involucrin

INVO_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07476
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IVL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5T7P4
Protein keywords

Cellular component

Cytoplasm

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

Isopeptide bondLipoprotein

Biological process

Keratinization

Domain

Repeat

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