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GnRHR Antibody

CAT: 0800-V7098-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7098-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH) . This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. [UniProt]
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT (1), Prediluted IHC only format: incubate for 30 min at RT (2)
UniProt
P30968
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the GnRHR antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
LCHR37
Applications
IF, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the GnRHR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This GnRHR antibody is available for research use only.
Storage Conditions
Store the GnRHR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human ovarian carcinoma and GnRHR antibody (clone LCHR37) . Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P30968

Gonadotropin-releasing hormone receptor

GNRHR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P30968
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GNRHR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
GnRH receptor, GnRH-R
EC number
—
Processing
—
Secondary accessions
O75793, Q14D13, Q92644
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

Disease

Disease variantHypogonadotropic hypogonadism

PTM

Disulfide bondGlycoprotein

Molecular function

G protein-coupled receptorReceptorTransducer

Domain

TransmembraneTransmembrane helix

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