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Podocalyxin Antibody

CAT: 0800-V3917-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V3917-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Podocalyxin/PODXL is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
O00592
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 310-447 from the human protein was used as the immunogen for the Podocalyxin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
PODXL/2185
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Podocalyxin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Podocalyxin antibody is available for research use only.
Storage Conditions
Store the Podocalyxin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Podocalyxin antibody should be determined by the researcher.
Location
Cell surface and cytoplasmic
Image Legend
IHC testing of FFPE human endometrium with Podocalyxin antibody (clone PODXL/2185) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
Product Datasheet
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