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Renalase Antibody

CAT: 0800-V3904SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3904SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Renalase is a 342 amino acid FAD-dependent amine oxidase that is highly expressed in kidney and is expressed at a lower level in heart, skeletal muscle and small intestine. Renalase is secreted in the blood by the kidney and it is thought to regulate cardiac function and systemic blood pressure. It is also suggested that Renalase functions as a hormone that metabolizes circulating catecholamines, which have an active role in the sympathetic and parasympathetic nervous systems. Individuals with chronic kidney disease and end-stage renal disease have markedly reduced levels of plasma Renalase than healthy individuals. Infusion of Renalase in animal models causes decrease in heart rate, cardiac contractility and blood pressure. Two isoforms of Renalase exist due to alternative splicing events.
CAS Number
9007-83-4
Specifications
ELISA (order BSA/sodium azide-free format for coating)
UniProt
Q5VYX0
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 34-235 from the human protein was used as the immunogen for the Renalase antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
RNLS/1940
Applications
ELISA
Purity
Protein G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the Renalase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Renalase antibody is available for research use only.
Storage Conditions
Store the Renalase antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Renalase antibody should be determined by the researcher.
Location
Secreted
Image Legend
IHC testing of FFPE human kidney with Renalase antibody (clone RNLS/1940) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · Q5VYX0

Renalase

RNLS_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q5VYX0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RNLS
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.6.3.5
Processing
Precursor
Secondary accessions
Q9BS33, Q9NUP8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

FADFlavoproteinNADNADP

Molecular function

Oxidoreductase

Cellular component

Secreted

Domain

Signal

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