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NGF Receptor Antibody

CAT: 0800-V3892-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3892-100UGSize:100 µg
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Description
It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR) . NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR is a reliable marker for desmoplastic and neurotropic melanomas. NGFR is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P08138
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein corresponding to amino acids 281-421 was used as the immunogen for the NGF Receptor antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
NGFR/1964
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the NGF Receptor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This NGF Receptor antibody is available for research use only.
Storage Conditions
Store the NGF Receptor antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the NGF Receptor antibody should be determined by the researcher.
Location
Cell surface and cytoplasmic
Image Legend
IHC testing of FFPE human adrenal gland with NGF Receptor antibody (clone NGFR/1964) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P08138

Tumor necrosis factor receptor superfamily member 16

TNR16_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08138
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NGFR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2R961, B4E096
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisBiological rhythmsDifferentiationNeurogenesis

Cellular component

Cell membraneCell projectionCytoplasmMembraneSynapse

Molecular function

Developmental proteinReceptor

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

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