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Ki-67 Antibody

CAT: 0800-V3866BTNSize: 500 µLDry Ice: NoHazardous: No
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CAT#:0800-V3866BTNSize:500 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ki-67 antigen is a nuclear, non-histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki-67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki-67 index and the histo-pathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors. Ki-67 labeling index has been shown to be a prognostic marker in a number of neoplasms including grade II astrocytoma, oligodendroglioma, colon carcinoma, and breast carcinoma. In general, Ki-67 is a good marker of proliferating cell populations.
CAS Number
9007-83-4
Specifications
Flow cytometry: 5ul per test per million cells, Immunofluorescence: 2-4 µg/mL at RT, Immunohistochemistry (FFPE) : 2-4 µg/mL at RT
UniProt
P46013
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 2293-2478 from the human protein was used as the immunogen for the Ki-67 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
MKI67/2465
Applications
FACS, IF, IHC-P
Purity
Protein G affinity chromatography
Format
Biotin Conjugate
Buffer
0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Ki-67 antibody at 2-8oC (up to one month) or aliquot and store at -20oC (longer term).
Limitations
This Ki-67 antibody is available for research use only.
Storage Conditions
Store the Ki-67 antibody at 2-8°C (up to one month) or aliquot and store at -20°C (longer term) .
Formulation
0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Ki-67 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using Ki-67 antibody (clone MKI67/2465) . These results demonstrate the foremost specificity of the MKI67/2465 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

UniProtKB · P46013

Proliferation marker protein Ki-67

KI67_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P46013
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MKI67
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5VWH2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycle

Cellular component

ChromosomeNucleus

Molecular function

DNA-binding

Domain

Repeat

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CAU36144-01Ki-67 Protein (Ki-67) Monoclonal Antibody
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TRV-004422-01Polyclonal Antibody to Ki-67 Protein (Ki-67)
030367Ki-67 (Antigen KI-67, MKI67, Ki67, Ki 67)
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