Emerin Antibody
CAT:
800-V3833-100UG
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Emerin Antibody
- Description: Emerin is a member of the nuclear lamina associated protein family. It is ubiquitously expressed and localized to the nuclear membrane in normal cells. Mutations of the gene that encodes emerin result in the X-linked recessive disease Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by slowly progressing contractures, skeletal muscle wasting and cardiomyopathy. Reportedly, lack of Emerin expression is one cause of EDMD. Emerin is involved in the association of the nuclear membrane with the lamina, and is localized specifically to desmosomes and fasciae adherents in the heart. Identification of nuclear membrane irregularities with anti-emerin antibody has been reported useful in diagnosing papillary thyroid carcinoma.
- CAS Number: 9007-83-4
- UniProt: P50402
- Host: Mouse
- Immunogen: A portion of amino acids 56-167 from the human protein was used as the immunogen for the Emerin antibody.
- Clonality: Monoclonal
- Isotype: IgG1 κ
- Applications: WB, IF, IHC-P
- Format: Purified
- Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
- Reconstitution: Store the Emerin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
- Limitations: This Emerin antibody is available for research use only.