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CD22 Antibody

CAT: 0800-V3786SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
V3786SAF-100UG100 µg
Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. [Uniprot]
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2 µg/mL
UniProt
P20273
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 52-178 from the human protein were used as the immunogen for the CD22 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
CDLA22-1
Applications
WB, FACS, IF
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the CD22 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD22 antibody is available for research use only.
Storage Conditions
Store the CD22 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
The stated application concentrations are suggested starting points. Titration of the CD22 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cell surface, cytoplasmic
Image Legend
Western blot testing of human Raji cell lysate with CD22 antibody (clone CDLA22-1) . Expected molecular weight: 76-150 kDa depending on glycosylation level.

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