CFTR Recombinant Antibody / Cystic Fibrosis Transmembrane Regulator

CFTR Recombinant Antibody / Cystic Fibrosis Transmembrane Regulator

• Description: CFTR functions as an ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl+/-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.[5] This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation. CFTR is found in the epithelial cells of many organs including the lung, liver, pancreas, digestive tract, and the reproductive tract. [Wiki]
• CAS Number: 9000-83-3
• UniProt: P13569
• Host: Mouse
• Immunogen: A recombinant human partial protein was used as the immunogen for this recombinant CFTR antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Type: Recombinant
• Applications: IHC-P
• Format: Purified
• Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
• Reconstitution: Store the recombinant CFTR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This recombinant CFTR antibody is available for research use only.