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Recombinant Beta-2 Microglobulin Antibody

CAT: 0800-V3538IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V3538IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
CAS Number
9000-83-3
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P61769
Host
Mouse
Reactivity
Human
Immunogen
Full length recombinant human protein was used as the immunogen for the recombinant Beta-2 Microglobulin antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG2b κ
Clone
RB2M/961
Type
Recombinant
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the recombinant Beta-2 Microglobulin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant Beta-2 Microglobulin antibody is available for research use only.
Storage Conditions
Store the recombinant Beta-2 Microglobulin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human lung carcinoma stained with recombinant Beta-2-Microglobulin antibody (rB2M/961) . Required HEIR: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P61769

Beta-2-microglobulin

B2MG_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61769
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
B2M
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
P01884, Q540F8, Q6IAT8, Q9UCK0, Q9UD48, Q9UDF4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

AmyloidMHC ISecreted

Disease

AmyloidosisDisease variant

PTM

Disulfide bondGlycationGlycoproteinPyrrolidone carboxylic acid

Biological process

Immunity

Domain

Immunoglobulin domainSignal
Product Datasheet
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