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CFTR Antibody

CAT: 0800-V3440-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V3440-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cystic fibrosis transmembrane conductance regulator (CFTR) is involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. [UniProt]
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P13569
Host
Mouse
Reactivity
Human
Immunogen
A partial recombinant protein corresponding to amino acids 258-385 from the human protein was used as the immunogen for this CFTR antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
CFTR/1785
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the CFTR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CFTR antibody is available for research use only.
Storage Conditions
Store the CFTR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CFTR antibody to be titered up or down for optimal performance.
Location
Cell surface, cytoplasmic
Image Legend
IHC testing of FFPE human pancreas with CFTR antibody (clone CFTR/1785) . HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH9 for 10-20 min followed by cooling at RT for 20 min.
Product Datasheet
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