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Factor XIIIa Antibody

CAT: 0800-V3431-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V3431-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Factor XIIIa has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells in the placenta, uterus, and prostate, monocytes and macrophages and dermal dendritic cells. Anti-Factor XIIIa has been found to be useful in differentiating between dermatofibroma (almost all cases are positive), dermatofibrosarcoma protuberans (-/+) and desmoplastic malignant melanoma (-) . Anti-Factor XIIIa positivity is also seen in capillary hemagioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor, and meningioma.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P00488
Host
Mouse
Reactivity
Human
Immunogen
A human partial recombinant protein corresponding to amino acids 46-181 was used as the immunogen for the Factor XIIIa antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
SPM180
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Factor XIIIa antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Factor XIIIa antibody is available for research use only.
Storage Conditions
Store the Factor XIIIa antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Titering of the Factor XIIIa antibody may be required for optimal performance.
Location
Cytoplasmic, secreted
Image Legend
IHC testing of FFPE human placenta with Factor XIIIa antibody (clone SPM180) . Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min.

UniProtKB · P00488

Coagulation factor XIII A chain

F13A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00488
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
F13A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Coagulation factor XIIIa
EC number
2.3.2.13
Processing
Precursor
Secondary accessions
Q59HA7, Q8N6X2, Q96P24, Q9BX29
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinZymogen

Molecular function

AcyltransferaseTransferase

Biological process

Blood coagulationHemostasis

Ligand

CalciumMetal-binding

Cellular component

CytoplasmSecreted

Disease

Disease variant

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