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S100B Antibody Cocktail

CAT: 0800-V3423SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3423SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
S100 belongs to the family of calcium binding proteins. S100A and S100B proteins are two members of the S100 family. S100A is composed of an alpha and a beta chain whereas S100B is composed of two beta chains. This antibody is specific against an epitope located on the beta-chain (i.e. in S-100A and S-100B) but not on the alpha-chain of S-100 (i.e. in S-100A and S100A0) . This antibody can be used to localize S-100A and S-100B in various tissue sections. S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly. A large number of well-differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein.
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 0.25-0.5 µg/mL for 30 min at RT
UniProt
P04271
Host
Mouse
Reactivity
Human
Immunogen
Purified bovine brain S100 protein (4C4.9) and recombinant full-length human protein (S100B/1012) were used as the immunogen for the S100 antibody cocktail.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
4C4.9 + S100B/1012
Applications
IF, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the S100B antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This S100B antibody cocktail is available for research use only.
Storage Conditions
Store the S100B antibody cocktail at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the S100B antibody cocktail should be determined by the researcher.
Location
Cytoplasmic, nuclear
Image Legend
(Left) Confocal Immunofluorescent analysis of A2058 cells using AF488-labeled S100 antibody (green) . F-actin filaments were labeled with DyLight 554 Phalloidin (red) . DAPI was used to stain the cell nuclei (blue) . (Right) Negative control.

UniProtKB · P04271

Protein S100-B

S100B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04271
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
S100B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
D3DSN6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Acetylation

Ligand

CalciumMetal-bindingZinc

Biological process

Cell adhesion

Cellular component

CytoplasmNucleusSecreted

Domain

Repeat
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