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WRR-483

CAT: 0804-HY-118338Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118338Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WRR-483 is an analog of K11777, an inhibitor of cruzain, used to inhibit the proliferation of Trypanosoma cruzi in cell culture. WRR-483 can eradicate parasitic infection in an acute Chagas disease mouse model. WRR-483 is an irreversible cysteine protease inhibitor that shows pH-dependent high affinity and potent trypanocidal activity against cruzain and T. cruzi infection, and is expected to inhibit Chagas disease.
CAS Number
1076088-50-0
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/wrr-483.html
Smiles
O=C(N1CCN(CC1)C)N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC2=CC=CC=C2)/C=C/S(=O)(C3=CC=CC=C3)=O)=O
Molecular Formula
C29H41N7O4S
Molecular Weight
583.75
References & Citations
[1]In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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