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Filaggrin Antibody

CAT: 0800-V3364-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3364-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Filaggrin is essential for the regulation of epidermal homeostasis. Within the stratum corneum, filaggrin monomers can become incorporated into the lipid envelope, which is responsible for the skin barrier function. Alternatively, these proteins can interact with keratin intermediate filaments. Filaggrin undergoes further processing in the upper stratum corneum to release free amino acids that assist in water retention. [Wiki]
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P20930
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human FLG protein was used as the immunogen for this Filaggrin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM181
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the Filaggrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Filaggrin antibody is available for research use only.
Storage Conditions
Store the Filaggrin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Filaggrin antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human skin with Filaggrin antibody (clone SPM181) . Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min.

UniProtKB · P20930

Filaggrin

FILA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20930
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FLG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q01720, Q5T583, Q9UC71
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-binding

PTM

CitrullinationPhosphoprotein

Domain

Coiled coilRepeat

Molecular function

Developmental protein

Disease

Ichthyosis

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