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CD61 Antibody / ITGB3 / Integrin beta 3

CAT: 0800-V3255-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V3255-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Reacts with human CD61, also called Integrin beta 3 (GPIIIa, vitronectin receptor beta chain) . It associates with the αV-chain (CD51) to form vitronectin receptor, or with the αIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61) . The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (Frozen & FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P05106
Host
Mouse
Reactivity
Human
Immunogen
Phytohemagglutinin (PHA) -stimulated peripheral blood cells were used as the immunogen for the CD61 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
Y2/51
Applications
IHC
Purity
Protein G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CD61 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD61 antibody is available for research use only.
Storage Conditions
Store the CD61 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Titration of the CD61 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cell surface, cytoplasmic
Image Legend
IHC testing of FFPE human spleen tissue with CD61 antibody (clone Y2/51) . Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min.

UniProtKB · P05106

Integrin beta-3

ITB3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05106
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGB3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0PJW2, D3DXJ8, O15495, Q12806, Q13413, Q14648, Q16499
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMagnesiumMetal-binding

Biological process

Cell adhesionHost-virus interaction

Cellular component

Cell junctionCell membraneCell projectionMembranePostsynaptic cell membraneSynapse

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Molecular function

Host cell receptor for virus entryIntegrinReceptor

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