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PSGL-1 Antibody / CD162

CAT: 0800-V3226-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3226-100UGSize:100 µg
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Description
P selectin glycoprotein ligand 1 (PSGL-1), also called CD162 glycoprotein, functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT
UniProt
Q14242
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human PSGL-1 protein was used as the immunogen for the PSGL-1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
PSGL1/1601
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the PSGL-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PSGL-1 antibody is available for research use only.
Storage Conditions
Store the PSGL-1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the PSGL-1 antibody should be determined by the researcher.
Location
Cell surface
Image Legend
IHC testing of FFPE human spleen with PSGL-1 antibody (clone PSGL1/1601) . Recommended HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min.

UniProtKB · Q14242

P-selectin glycoprotein ligand 1

SELPL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14242
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SELPLG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PSGL-1
EC number
—
Processing
Precursor
Secondary accessions
A8K2Y0, B4DQC3, B7Z5C7, J3KMX6, Q12775, Q6GTW7, Q8N7J7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesionHost-virus interaction

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoproteinPyrrolidone carboxylic acidSulfation

Molecular function

Host cell receptor for virus entryReceptor

Cellular component

Membrane

Domain

RepeatSignalTransmembraneTransmembrane helix

Ligand

Sialic acid

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