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Beta Catenin Antibody

CAT: 0800-V3209-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V3209-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. [RefSeq]
CAS Number
9007-83-4
Specifications
Flow cytometry: 0.5-1ug/10^6 cells, Immunofluorescence: 1-2 µg/mL, Western blot: 0.5-1 µg/mL
UniProt
P35222
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant fusion protein consisting of the N-terminal half of human beta-Catenin fused to maltose binding protein was used as the immunogen for the Beta Catenin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
12F7
Applications
FACS, IF, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Beta Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Beta Catenin antibody is available for research use only.
Storage Conditions
Store the Beta Catenin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Titration of the Beta Catenin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cell surface, cytoplasmic, cell junctions
Image Legend
Western blot testing of human 1) A431, 2) A549 and 3) MCF7 cell lysate with Beta Catenin antibody (clone 12F7) . Predicted molecular weight ~85 kDa, but routinely observed at 90-95 kDa.
Product Datasheet
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