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MVP Antibody

CAT: 0800-V3044IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V3044IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP) . Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
Q14764
Host
Mouse
Reactivity
Human
Immunogen
Proteins precipitated from human breast cancer MCF-7 cells were used as the immunogen for the MVP antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM280
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the MVP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This MVP antibody is available for research use only.
Storage Conditions
Store the MVP antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic, nuclear
Image Legend
IHC: Formalin-fixed, paraffin-embedded human testicular carcinoma stained with MVP antibody (clone SPM280) .

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