CLIP Antibody

CAT: 0800-V3036-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V3036-100UGSize:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes proteins of 33, 35 and 41kDa, which are identified as various isoforms of CD74/CLIP. Its epitope is localized in the extracellular domain of CD74. CD74/CLIP is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74/CLIP is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, and dendritic cells and by various types of carcinomas. It is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74/CLIP stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas and has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+) .
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL
UniProt
P04233
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the CLIP antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CLIP/1133
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CLIP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CLIP antibody is available for research use only.
Storage Conditions
Store the CLIP antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CLIP antibody should be determined by the researcher.
Location
Cell surface and paranuclear globular
Image Legend
Western blot analysis of Raji cell lysate using CLIP antibody (CLIP/1133) . Expected molecular weight: 33-43 kDa.
Product Datasheet
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