Products for Research Use Only
RegisterLogin

CD59 Antibody

CAT: 0800-V3024-100UGSize: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-V3024-100UGSize:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Reacts with human CD59, a 20kDa glycosyl phosphatidyl-inositol (GPI) -anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH) . It is useful for study on GPI-anchored proteins, PNH and CD59 functions.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P13987
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the CD59 antibody.
Clonality
Monoclonal
Isotype
IgM k
Clone
MACIF/1193
Applications
IHC-P
Purity
PEG precipitation
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CD59 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD59 antibody is available for research use only.
Storage Conditions
Store the CD59 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Plasma membrane, cytoplasm
Image Legend
IHC: Formalin-fixed, paraffin-embedded human tongue stained with CD59 antibody (MACIF/1193)

Related Products

CatalogName
V9218-20UGCD5 Ligand Antibody / CD5L
V9218SAF-100UGCD5 Ligand Antibody / CD5L
V9218-100UGCD5 Ligand Antibody / CD5L
V9054-20UGCD56 Antibody
V3019-100UGCD53 Antibody
F40384-0.08MLCD55 Antibody
RQ6960CD55 Antibody
V2535SAF-100UGCD57 Antibody
V2533SAF-100UGCD57 Antibody
V7487-100UGCD56 Antibody

Alternative Products

CatalogName
abx100401-01CD59 Glycoprotein (CD59) Antibody

Popular Products