Products for Research Use Only
RegisterLogin

ZAP70 Antibody

CAT: 0800-V2935SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-V2935SAF-100UGSize:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P43403
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein (including amino acids 1-254 and the SH2 domains) was used as the immunogen for the ZAP70 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
SPM362
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the ZAP70 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This ZAP70 antibody is available for research use only.
Storage Conditions
Store the ZAP70 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human tonsil stained with ZAP70 antibody (clone SPM362) .

UniProtKB · P43403

Tyrosine-protein kinase ZAP-70

ZAP70_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P43403
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ZAP70
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.2
Processing
—
Secondary accessions
A6NFP4, Q6PIA4, Q8IXD6, Q9UBS6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Biological process

Adaptive immunityImmunity

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmMembrane

Disease

Disease variantSCID

Molecular function

KinaseTransferaseTyrosine-protein kinase

Domain

RepeatSH2 domain

Related Products

CatalogName
V7816-100UGGlycoprotein 2 Antibody / GP2 / ZAP75
V3873SAF-100UGGlycoprotein 2 Antibody / GP2 / ZAP75
V7816-20UGGlycoprotein 2 Antibody / GP2 / ZAP75
V3872-20UGGP2 Antibody / Glycoprotein 2 / ZAP75
V3333-20UGGP2 Antibody / Glycoprotein 2 / ZAP75
V7816SAF-100UGGlycoprotein 2 Antibody / GP2 / ZAP75
V3333-100UGGP2 Antibody / Glycoprotein 2 / ZAP75
V4410-20UGGlycoprotein 2 Antibody / GP2 / ZAP75
V3333SAF-100UGGP2 Antibody / Glycoprotein 2 / ZAP75
V4410-100UGGlycoprotein 2 Antibody / GP2 / ZAP75

Alternative Products

CatalogName
GTR17857109ZAP70 Antibody

Popular Products