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Transgelin Antibody

CAT: 0800-V2878IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V2878IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This mAb recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
Q01995
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the Transgelin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM606
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the Transgelin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Transgelin antibody is available for research use only.
Storage Conditions
Store the Transgelin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human colon carcinoma stained with Transgelin antibody (SPM606) .

UniProtKB · Q01995

Transgelin

TAGL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q01995
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TAGLN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O15542
Protein keywords

PTM

AcetylationMethylationPhosphoprotein

Molecular function

Actin-bindingMuscle protein

Cellular component

Cytoplasm

Technical term

Proteomics identificationReference proteome

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