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PTH Antibody / C-Terminal

CAT: 0800-V2811-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V2811-100UGSize:100 µg
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Description
Epitope of this mAb maps in the C-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH) ; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT
UniProt
P01270
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 32-115 of human PTH was used as the immunogen for the Parathyroid Hormone antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
PTH/1175
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the PTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PTH antibody is available for research use only.
Storage Conditions
Store the PTH antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic and secreted
Image Legend
IHC: Formalin-fixed, paraffin-embedded human parathyroid stained with PTH antibody (PTH/1175) .

UniProtKB · P01270

Parathyroid hormone

PTHY_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01270
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTH
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PTH
EC number
—
Processing
Precursor
Secondary accessions
Q4VB48, Q9UD38
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Cleavage on pair of basic residues

Disease

Disease variant

Molecular function

Hormone

Cellular component

Secreted

Domain

Signal
Product Datasheet
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