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NGF Receptor Antibody

CAT: 0800-V2764-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V2764-100UGSize:100 µg
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Description
It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR) . NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P08138
Host
Mouse
Reactivity
Human
Immunogen
NGFR from A875 melanoma cells was used as the immunogen for the NGF Receptor antibody. Its epitope is within amino acids 1-160 of the extracellular domain of NGFR/NTR.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM299
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the NGF Receptor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This NGF Receptor antibody is available for research use only.
Storage Conditions
Store the NGF Receptor antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface and cytoplasmic
Image Legend
IHC analysis of formalin-fixed, paraffin-embedded human adrenal gland stained with NGF Receptor antibody (clone SPM299) .

UniProtKB · P08138

Tumor necrosis factor receptor superfamily member 16

TNR16_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08138
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NGFR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2R961, B4E096
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisBiological rhythmsDifferentiationNeurogenesis

Cellular component

Cell membraneCell projectionCytoplasmMembraneSynapse

Molecular function

Developmental proteinReceptor

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

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