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P75NTR Antibody

CAT: 0800-V2763IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V2763IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR) . NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P08138
Host
Mouse
Reactivity
Human
Immunogen
NGFR from A875 melanoma cells was used as the immunogen for the p75NTR antibody. Its epitope has been localized to amino acids 1-160 of the extracellular domain of NGFR/NTR.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
NGFR5
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the p75NTR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This p75NTR antibody is available for research use only.
Storage Conditions
Store the p75NTR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cell surface and cytoplasmic
Image Legend
IHC analysis of formalin-fixed, paraffin-embedded human melanoma stained with p75NTR antibody (clone NGFR5) .

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