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C-Myc Antibody

CAT: 0800-V2744-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V2744-100UGSize:100 µg
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Description
It recognizes a transcription factor of 64-67kDa, identified as c-myc. Its epitope spans between aa 410-419 (EQKLISEEDL) which is a specific portion of an alpha helical region of human c-myc protein. This mAb shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P01106
Host
Mouse
Reactivity
Human
Immunogen
Amino acids AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA were used as the immunogen for the c-Myc antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
9E10.3
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the c-Myc antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This c-Myc antibody is available for research use only.
Storage Conditions
Store the c-Myc antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Nuclear
Image Legend
IHC analysis of formalin-fixed, paraffin-embedded human cervical carcinoma stained with c-Myc antibody (clone 9E10.3) .

UniProtKB · P01106

Myc proto-oncogene protein

MYC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01106
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MYC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A0A024R9L7, A0A087WUS5, A8WFE7, H0YBT0, P01107, Q14026
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative initiationAlternative splicingChromosomal rearrangement

Cellular component

ChromosomeCytoplasmNucleus

Disease

Proto-oncogene

Biological process

TranscriptionTranscription regulation

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