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Involucrin Antibody

CAT: 0800-V2647IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V2647IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this mAb reacts with a 120kDa protein. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P07476
Host
Mouse
Reactivity
Human
Immunogen
Purified involucrin from human keratinocytes was used as the immunogen for the Involucrin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
IVRN/827
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the Involucrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Involucrin antibody is available for research use only.
Storage Conditions
Store the Involucrin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human tonsil stained with Involucrin antibody (clone IVRN/827) .

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