Tenascin C Antibody

CAT: 0800-V2602-100UGSize: 100 µgDry Ice: NoHazardous: No

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CAT#:0800-V2602-100UGSize:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

In Western blotting, it reacts with two bands of ~MW of 210kDa and 300kDa, identified as two isoforms of Tenascin C. Specificity of this mAb is validated by sequential immunoprecipitation with a PAb against Tenascin C. Tenascin C is a multifunctional, disulfide-linked hexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neo-vasculature and stroma of undifferentiated tumors. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyper-proliferative diseases and in stroma of many neoplasms, including gliomas, breast, squamous and lung carcinomas.

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 2-4 µg/mL for 30 min at RT

UniProt

P24821

Host

Mouse

Reactivity

Human

Immunogen

Human breast carcinoma cells were used as the immunogen for the Tenascin C antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

T2H5

Applications

IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Reconstitution

Store the Tenascin C antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This Tenascin C antibody is available for research use only.

Storage Conditions

Store the Tenascin C antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Location

Connective tissue matrix

Image Legend

IHC: Formalin-fixed, paraffin-embedded human lung carcinoma stained with Tenascin C antibody (T2H5) at 4ug/ml. Antigen retrieval in 10mM Tris with 1mM EDTA, pH 9.0; ABC detection system with DAB Chromogen. Note staining of connective tissue.

UniProtKB · P24821

Tenascin

TENA_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P24821
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: TNC
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: TN
EC number: —
Processing: Precursor
Secondary accessions: C9IYT7, C9J575, C9J6D9, C9J848, Q14583, Q15567, Q5T7S3

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

Domain

Coiled coilEGF-like domainRepeatSignal

Disease

DeafnessDisease variantNon-syndromic deafness

PTM

Disulfide bondGlycoproteinPhosphoproteinProteoglycan

Cellular component

Extracellular matrixSecreted

Product Datasheet

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Alternative Products

Catalog	Name
10R-T103a	Tenascin antibody
60R-1712	Tenascin antibody (FITC)
MBS9611996-01	Tenascin-N Antibody
MBS9435656-01	Tenascin C Antibody
ASA-B1844	Tenascin Antibody (monoclonal)
OM636225-01	Tenascin-X Antibody
abx108801-01	Tenascin Antibody (HRP)
abx110255-01	Tenascin (TNC) Antibody
abx105966-01	Tenascin Antibody (Biotin)
C30262-01	Tenascin-R Antibody