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FSH-beta Antibody

CAT: 0800-V2509-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V2509-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This mAb reacts with a protein of 22 kDa, identified as beta sub-unit of FSH. It does not cross react with the alpha sub-unit. Follicle stimulating hormone (FSH) is a hormone synthesized and secreted by gonadotrophs in the anterior pituitary gland. In the ovary, FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows, it releases inhibin, which deactivates the FSH production. In men, FSH enhances the production of androgen-binding protein by the Sertoli cells of the testis and is critical for spermatogenesis. FSH and LH act synergistically in reproduction. FSH is a useful marker in the classification of pituitary tumors and the study of pituitary disease.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT (1) (2)
UniProt
P01225
Host
Mouse
Reactivity
Human
Immunogen
Recombinant hFSH beta sub-unit was used as the immunogen for the FSH-beta antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
FSHb/1062
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the FSH-beta antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This FSH-beta antibody is available for research use only.
Storage Conditions
Store the FSH-beta antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic, secreted
Image Legend
IHC: Formalin-fixed, paraffin-embedded human pituitary stained with FSH-beta antibody (clone FSHb/1062) .

UniProtKB · P01225

Follitropin subunit beta

FSHB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01225
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FSHB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A2TF08, A5JVV3, Q14D61
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Disease

Disease variantHypogonadotropic hypogonadism

PTM

Disulfide bondGlycoprotein

Molecular function

Hormone

Cellular component

Secreted

Domain

Signal

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