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CEA Antibody / CEACAM5

CAT: 0800-V2444SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V2444SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This antibody recognizes proteins of 80-200kDa, identified as different members of CEA family. CEA is synthesized during development in the fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. This mAb reacts with nonspecific cross-reacting antigen (NCA) . It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+) . Anti-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and endocervix.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.25-0.5 µg/mL for 30 min at RT (1) (2)
UniProt
P06731
Host
Mouse
Reactivity
Human
Immunogen
Purified human protein was used as the immunogen for the CEA antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
C66/1260
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the CEA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CEA antibody is available for research use only.
Storage Conditions
Store the CEA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cytoplasmic and luminal surface
Image Legend
IHC: Formalin-fixed, paraffin-embedded human colon carcinoma stained with CEA antibody (C66/1260) .

UniProtKB · P06731

Cell adhesion molecule CEACAM5

CEAM5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06731
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CEACAM5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
H9KVA7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCell adhesion

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinGPI-anchorLipoprotein

Domain

Immunoglobulin domainRepeatSignal

Disease

Oncogene

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