Bcl10 Antibody

Bcl10 Antibody

• Description: Bcl10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1;14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of Bcl10 was shown to induce NFkB activation in a NIK-dependent pathway. This antibody labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1;14) translocation, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.
• CAS Number: 9007-83-4
• Host: Mouse
• Immunogen: Human Bcl10 recombinant protein (epitope localized to amino acids 122-168) was used as the immunogen for this antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Applications: FACS, WB, IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
• Reconstitution: Store the Bcl10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This Bcl10 antibody is available for research use only.